Fonzi L, Kaistas V, Gasparoni A, Belli M, Capezzuoli L
Institut d'Anatomie Humaine Normale, Université de Sienne.
Bull Group Int Rech Sci Stomatol Odontol. 1992 Mar-Jun;35(1-2):13-21.
The major goal endodontic therapy has been achieved by condensing filling materials into the root canal. It's not uncommon to find excess material into the periapical tissue. It therefore becomes obligatory to use fillings materials that have acceptable biocompatibility. The purpose of this investigation was to obtain a "toxicity profile" of some endodontics materials and to compare our observations to results present in literature. The gutta-percha and five endodontic filling cements were tested "in vivo" and "in vitro". The in vivo biocompatibility involved the placement of the test material in 10 mm. Teflon tubes with an outer diameter of 1.3 mm which were implanted subcutaneously into rats. The implants were left in situ for periods of 30 and 90 days. The "hemolysis test" is designed for "in vitro" evaluations. The histological examination showed different intensity and extent cellular responses. In some cases severe infiltration of inflammatory cell and areas with necrotic were seen. At conclusion, the endodontics material evaluated showed slight, moderate and severe reactions; therefore a different pattern in tissue response.
通过将充填材料压实到根管中，牙髓治疗的主要目标已达成。在根尖周组织中发现多余材料的情况并不少见。因此，使用具有可接受生物相容性的充填材料就变得必不可少。本研究的目的是获得一些牙髓材料的“毒性概况”，并将我们的观察结果与文献中的结果进行比较。对牙胶和五种牙髓充填粘固剂进行了“体内”和“体外”测试。体内生物相容性涉及将测试材料放置在10毫米、外径为1.3毫米的聚四氟乙烯管中，这些管子皮下植入大鼠体内。植入物原位放置30天和90天。“溶血试验”用于“体外”评估。组织学检查显示了不同强度和程度的细胞反应。在某些情况下，可见炎症细胞的严重浸润和坏死区域。总之，所评估的牙髓材料显示出轻微、中度和重度反应；因此，组织反应模式不同。
