Pelgeroid样异常细胞在与骨髓增生异常综合征相关的嗜中性皮肤病诊断中的作用

Pelgeroid-like anomalous cells in the diagnosis of neutrophilic dermatosis associated with myelodysplastic syndrome.

作者信息

Nogita T, Morioka N, Ishibashi Y, Kawashima M, Mizoguchi M, Otsuka F

机构信息

Department of Dermatology, Tokyo Women's Medical College, Japan.

出版信息

Int J Dermatol. 1992 Dec;31(12):864-5. doi: 10.1111/j.1365-4362.1992.tb03544.x.

DOI:10.1111/j.1365-4362.1992.tb03544.x

PMID:1478765

Abstract

Neutrophilic dermatoses (ND), with or without accompanying myelodysplastic syndrome (MDS), were examined in terms of nuclear abnormality like pelgeroid anomaly of infiltrating cells into skin lesions. Six ND accompanying MDS showed 1.0 to 13.5% of such anomalous cells among infiltrating cells. In contrast, ND without accompanying myeloproliferative disorders rarely had such anomalous cells. Our findings suggest that pelgeroid-like anomalous cells infiltrating into ND are probably a good marker of underlying MDS.

摘要

对伴有或不伴有骨髓增生异常综合征（MDS）的嗜中性皮病（ND）进行了检查，观察其皮肤病变浸润细胞的核异常情况，如Pelger样异常。6例伴有MDS的ND患者，浸润细胞中此类异常细胞占1.0%至13.5%。相比之下，不伴有骨髓增殖性疾病的ND很少有此类异常细胞。我们的研究结果表明，浸润到ND中的Pelger样异常细胞可能是潜在MDS的一个良好标志物。