Tomasini C, Aloi F, Osella-Abate S, Dapavo P, Pippione M
Department of Medical and Surgical Specialties, Second Dermatologic Clinic, University of Turin, Italy.
Am J Dermatopathol. 2000 Oct;22(5):429-33. doi: 10.1097/00000372-200010000-00008.
Sweet syndrome (SS) associated with myeloproliferative disorders has been considered an inflammatory process mediated by neutrophils in which immunologic mechanisms are operative. The authors report the case of a 68-year-old man suffering from a myelodysplastic syndrome, who presented with a relapsing skin eruption resembling SS. Histopathologically, the skin infiltrates showed prominent neutrophilic features masking the underlying malignant process. Extensive immunophenotypic studies of skin revealed the presence of a few immature myeloid cells intermingled with an overwhelming infiltrate of neutrophils. The atypical cells in the skin had a phenotype identical to that of leukemic cells in the peripheral blood and bone marrow. Whether or not immature myeloid cell precursors constitute a specific infiltrate of leukemia cutis or are a result of recruitment of circulating leukemic cells to this area of inflammation is discussed.
与骨髓增殖性疾病相关的Sweet综合征被认为是一种由中性粒细胞介导的炎症过程，其中免疫机制起作用。作者报告了一例68岁患有骨髓增生异常综合征的男性病例，该患者出现了类似Sweet综合征的复发性皮疹。组织病理学上，皮肤浸润显示出突出的中性粒细胞特征，掩盖了潜在的恶性过程。对皮肤进行的广泛免疫表型研究显示，有一些未成熟髓样细胞与大量中性粒细胞浸润混合存在。皮肤中的非典型细胞具有与外周血和骨髓中白血病细胞相同的表型。本文讨论了未成熟髓样细胞前体是否构成皮肤白血病的特异性浸润，或者是循环白血病细胞募集到该炎症区域的结果。
