Dinneen S F, O'Mahony M S, O'Brien T, Cronin C C, Murray D M, O'Sullivan D J
Department of Medicine, Cork Regional Hospital, Ireland.
Ir J Med Sci. 1992 Nov;161(11):636-8. doi: 10.1007/BF02983771.
Serum ferritin was measured in 50 patients at diagnosis of diabetes mellitus (DM) and in 20 patients with established DM and poor metabolic control. Twenty-two patients had hyperferritinemia at diagnosis. Four patients had a recognised cause for their hyperferritinemia. In the remaining 18 patients ferritin levels decreased from a mean of 506 +/- 3.6 (SE) ug/l at diagnosis to 254 +/- 29.2 ug/l seven months later (p < 0.001). Metabolic control improved significantly over the same time. All 20 patients with established DM and poor metabolic control had normal ferritin levels. When compared with the newly diagnosed hyperferritinemic patients no difference was found in levels of glycosylated haemoglobin, but ferritin values differed significantly between the two groups (p < 0.001). These results indicate that transient hyperferritinemia is a feature of newly diagnosed DM but not of established DM with poor control. If used to screen diabetic patients for haemochromatosis, serum ferritin should be measured in established DM rather than at diagnosis.
在50例糖尿病（DM）诊断患者以及20例确诊DM且代谢控制不佳的患者中检测了血清铁蛋白。22例患者在诊断时存在高铁蛋白血症。4例患者的高铁蛋白血症有已知病因。其余18例患者的铁蛋白水平从诊断时的平均506±3.6（SE）μg/L降至7个月后的254±29.2μg/L（p<0.001）。同期代谢控制显著改善。所有20例确诊DM且代谢控制不佳的患者铁蛋白水平均正常。与新诊断的高铁蛋白血症患者相比，糖化血红蛋白水平无差异，但两组间铁蛋白值差异显著（p<0.001）。这些结果表明，短暂性高铁蛋白血症是新诊断DM的一个特征，而非确诊且控制不佳的DM的特征。若用于筛查糖尿病患者的血色素沉着症，应在确诊DM时而非诊断时检测血清铁蛋白。
