Riederer B M
Institut d'Anatomie, Université de Lausanne, Switzerland.
Histochem J. 1992 Nov;24(11):783-90. doi: 10.1007/BF01046350.
The cytoskeleton is important for neuronal morphogenesis. During the postnatal development of cat brain, the molecular composition of the neuronal cytoskeleton changes with maturation. Several of its proteins change in their rate of expression, in their degree of phosphorylation, in their subcellular distribution, or in their biochemical properties. It is proposed that phosphorylation is an essential mechanism to regulate the plasticity of the early, juvenile-type cytoskeleton. Among such proteins are several microtubule-associated proteins (MAPs), such as MAP5a, MAP2c or the juvenile tau proteins. Phosphorylation may also act on neurofilaments, postulated to be involved in the adult-type stabilization of axons. These observations imply that phosphorylation may affect cytoskeleton function in axons and dendrites at various developmental stages. Yet, the mechanisms of phosphorylation and its regulation cascades are largely unknown. In view of the topic of this issue on CD15, the potential role of matrix molecules being involved in the modulation of phosphorylation activity and of cytoskeletal properties is addressed.
细胞骨架对神经元形态发生很重要。在猫脑出生后的发育过程中，神经元细胞骨架的分子组成随成熟而变化。其几种蛋白质在表达速率、磷酸化程度、亚细胞分布或生化特性方面发生变化。有人提出，磷酸化是调节早期幼年型细胞骨架可塑性的重要机制。这类蛋白质中有几种微管相关蛋白（MAPs），如MAP5a、MAP2c或幼年tau蛋白。磷酸化也可能作用于神经丝，推测其参与轴突的成年型稳定。这些观察结果表明，磷酸化可能在不同发育阶段影响轴突和树突中的细胞骨架功能。然而，磷酸化及其调节级联反应的机制在很大程度上尚不清楚。鉴于本期关于CD15的主题，探讨了基质分子在调节磷酸化活性和细胞骨架特性方面的潜在作用。
