Mareck A, Fellous A, Francon J, Nunez J
Nature. 1980 Mar 27;284(5754):353-5. doi: 10.1038/284353a0.
The onsert of neuronal differentiation is characterised by intensive neurite growth; because microtubule formation is strictly required during this process, in vitro assembly of the tubulin present in the rat brain has been studied at different stages of development: the rate of assembly is very slow in the early stages and increases progressively with age from birth until adulthood. Other data also suggested that the limiting factor in the young brain is the amount or activity of one or several of the minor components which co-polymerise into microtubules with tubulin. We show here that both the composition and the activity of the microtubule-associated proteins change during the time course of rat brain development.
神经元分化的开始以强烈的神经突生长为特征；由于在此过程中严格需要微管形成，因此已经在发育的不同阶段研究了大鼠脑中存在的微管蛋白的体外组装：组装速率在早期非常缓慢，从出生到成年随着年龄的增长逐渐增加。其他数据还表明，幼脑的限制因素是与微管蛋白共聚合形成微管的一种或几种次要成分的数量或活性。我们在此表明，微管相关蛋白的组成和活性在大鼠脑发育过程中都会发生变化。
