Ju G, Zhang X
Department of Neurobiology, Fourth Military Medical University, Xi'an, People's Republic of China.
J Comp Neurol. 1992 Dec 1;326(1):101-11. doi: 10.1002/cne.903260109.
Our previous studies have demonstrated the presence of a considerable number of substance P-, calcitonin gene-related peptide (CGRP)-, and galanin-like immunoreactive (LI) nerve fibers in the anterior pituitary in several mammalian species. The present study investigated the ultrastructure of the CGRP-LI innervation of this gland in the dog. The CGRP-LI nerve fibers were unmyelinated, with a wealth of varicosities containing both small clear synaptic vesicles and large dense-cored vesicles. They were found to be in direct contact with every cell type of the anterior pituitary. However, only on corticotropes and somatotropes were CGRP-LI synaptic contacts identified. Most of them were asymmetrical in type. Occasional symmetrical synaptic contacts were also found. It is considered likely that direct neural factors may play a role in the regulation of the anterior pituitary.
我们之前的研究已证实在几种哺乳动物物种的垂体前叶中存在相当数量的P物质、降钙素基因相关肽（CGRP）和甘丙肽样免疫反应性（LI）神经纤维。本研究调查了犬类该腺体CGRP-LI神经支配的超微结构。CGRP-LI神经纤维无髓鞘，有大量含有小而清亮突触小泡和大而致密核心小泡的膨体。发现它们与垂体前叶的每种细胞类型都有直接接触。然而，仅在促肾上腺皮质激素细胞和生长激素细胞上鉴定出CGRP-LI突触接触。其中大多数为不对称型。也发现了偶尔的对称突触接触。认为直接神经因素可能在垂体前叶的调节中起作用。
