Ju G, Zhang X
Department of Neurobiology, Fourth Military Medical University, Xian, People's Republic of China.
Neuroscience. 1990;38(2):503-13. doi: 10.1016/0306-4522(90)90046-7.
The pars distalis of the adenohypophysis has recently been proved to be innervated by substance P-like immunoreactive nerve fibers in the monkey and the dog. The present study investigated immuno-electron microscopically the morphology of these nerve fibers and their relationship to anterior pituitary gland cells in the dog. The nerve fibers were unmyelinated and varicose. Direct contacts between them and every cell type of the gland could be ascertained, including folliculostellate cells. Typical synapses were identified on somatotropes and corticotropes. Most of them were of asymmetrical type with round to oval small clear vesicles and scattered large dense-cored vesicles. Occasional symmetrical type synapses were also seen. The results imply that substance P-like immunoreactive nerve fibers have an effector role in the pars distalis of the dog.
最近已证实，在猴和犬中，腺垂体远侧部受P物质样免疫反应性神经纤维的支配。本研究采用免疫电子显微镜研究了犬中这些神经纤维的形态及其与腺垂体细胞的关系。神经纤维无髓且有曲张。可以确定它们与腺体内每种细胞类型（包括滤泡星状细胞）之间有直接接触。在生长激素细胞和促肾上腺皮质激素细胞上发现了典型的突触。其中大多数是不对称型的，有圆形至椭圆形的小清亮囊泡和散在的大致密核心囊泡。偶尔也可见对称型突触。结果表明，P物质样免疫反应性神经纤维在犬腺垂体远侧部具有效应作用。
