Kawamoto K, Uozumi T, Yano T, Arita K, Kurisu K, Kiya K
Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
Int J Hyperthermia. 1992 Nov-Dec;8(6):747-54. doi: 10.3109/02656739209005022.
Effects of hyperthermia alone and combined with bromocriptine (BC) or a somatostatin analogue (SMS 201-995) were studied in vitro on normal pituitary and pituitary tumour cells (GH3 cells). GH3 cells were more sensitive to heat than normal pituitary cells and a maximal difference in survival was obtained with hyperthermia at 42.5 degrees C for 6 h. BC had cytotoxic and antiproliferative effects on GH3 cells, whereas SMS 201-995 was not effective. Hyperthermia at 42.5 degrees C for 3 h in combination with BC enhanced selective cytotoxicity for GH3 cells. In contrast, combined treatment with hyperthermia and SMS 201-995 failed to enhance cytotoxicity for GH3 cells. The combination of hyperthermia and BC could provide improved therapeutic efficacy in patients with pituitary adenomas.
在体外研究了单纯热疗以及热疗联合溴隐亭（BC）或生长抑素类似物（SMS 201-995）对正常垂体细胞和垂体肿瘤细胞（GH3细胞）的影响。GH3细胞比正常垂体细胞对热更敏感，在42.5℃热疗6小时时存活差异最大。BC对GH3细胞具有细胞毒性和抗增殖作用，而SMS 201-995无效。42.5℃热疗3小时联合BC增强了对GH3细胞的选择性细胞毒性。相反，热疗与SMS 201-995联合治疗未能增强对GH3细胞的细胞毒性。热疗与BC联合应用可为垂体腺瘤患者提供更好的治疗效果。
