Becker J T, Lopez O L, Wess J
Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania.
J Neurol Neurosurg Psychiatry. 1992 Dec;55(12):1177-81. doi: 10.1136/jnnp.55.12.1177.
This study extends previous work analysing functional dissociations occurring in patients with Alzheimer's disease (AD) by demonstrating that material-specific memory loss is common. The pattern of neuropsychological dysfunction in 191 patients with probable AD was examined and 13% presented with material-specific memory loss. Thirteen patients had impaired immediate verbal recall, but normal non verbal recall and 12 had impaired non verbal recall and normal verbal memory. These patterns appeared to be related to a specific memory deficit and were probably not secondary to associated cognitive impairments. These data confirm earlier observations that the memory defect in AD can be material-specific, and suggest that these patterns of impairment should be viewed as a focal sparing of function.
本研究通过证明材料特异性记忆丧失很常见，扩展了先前对阿尔茨海默病（AD）患者发生的功能分离的分析工作。对191例可能患有AD的患者的神经心理功能障碍模式进行了检查，13%的患者表现出材料特异性记忆丧失。13例患者即时言语回忆受损，但非言语回忆正常，12例患者非言语回忆受损且言语记忆正常。这些模式似乎与特定的记忆缺陷有关，可能不是继发于相关的认知障碍。这些数据证实了早期的观察结果，即AD中的记忆缺陷可能是材料特异性的，并表明这些损伤模式应被视为功能的局灶性保留。
