Brooks J G, Fleming P J, Berry P J, Golding J
Department of Pediatrics, University of Rochester, New York.
Pediatr Pulmonol. 1992 Nov;14(3):171-9. doi: 10.1002/ppul.1950140306.
To evaluate the clinical usefulness (sensitivity and specificity) of the Oxford and Sheffield birth scores for prospective identification of infants at high risk of SIDS.
Retrospective medical record reviews of prospectively identified, autopsy-validated SIDS and living control infants.
Consecutive sample of 140 infants, born between 1/1/83 and 12/31/87, who died suddenly and unexpectedly in the Avon Area Health Authority in southwest England between 1/1/84 and 12/31/88. Seventeen of the cases were excluded: 6 because they lacked adequate clinical records, 11 because they were not SIDS. The 637 control infants were comprised of every 80th delivery between 1/1/83 and 12/31/87 in the three major hospitals in the area.
SIDS incidence was 2.85/1,000 live births. Using standard cut scores to define high SIDS risk (2.0 for Oxford and 500 for Sheffield), sensitivities were 0.55 and 0.35 and specificities were 0.78 and 0.89 for the Oxford and Sheffield scores, respectively. SIDS risk for infants in the high risk group was 7.3/1,000 (Oxford) and 9.3/1,000 (Sheffield).
Since there is no intervention with proven efficacy for SIDS prevention, and since approximately one half of SIDS cases occur in low risk groups, clinical use of these scoring systems for allocation of health care resources or personnel for the sole purpose of SIDS prevention is not justified.
评估牛津和谢菲尔德出生评分在前瞻性识别婴儿猝死综合征(SIDS)高危婴儿方面的临床实用性(敏感性和特异性)。
对前瞻性识别的、经尸检证实的SIDS婴儿和存活对照婴儿进行回顾性病历审查。
连续抽取了140名婴儿作为样本,这些婴儿于1983年1月1日至1987年12月31日出生,在1984年1月1日至1988年12月31日期间于英格兰西南部的埃文地区卫生局突然意外死亡。其中17例被排除:6例因缺乏足够的临床记录,11例因并非SIDS。637名对照婴儿包括该地区三家主要医院在1983年1月1日至1987年12月31日期间每第80次分娩的婴儿。
SIDS发病率为2.85/1000活产。使用标准截断分数定义SIDS高风险(牛津评分2.0,谢菲尔德评分500),牛津评分和谢菲尔德评分的敏感性分别为0.55和0.35,特异性分别为0.78和0.89。高危组婴儿的SIDS风险为7.3/1000(牛津评分)和9.3/1000(谢菲尔德评分)。
由于尚无经证实有效的SIDS预防干预措施,且约一半的SIDS病例发生在低风险组,因此仅为预防SIDS而将这些评分系统用于分配医疗保健资源或人员的临床应用是不合理的。