Roy P, Coleman M P
Centre international de Recherche sur le Cancer, Lyon, France.
Rev Epidemiol Sante Publique. 1992;40(5):323-34.
Acute lymphocytic leukaemia (ALL) has a bimodal age incidence. It constitutes the majority of leukaemias diagnosed in childhood but less than 5% of adult leukaemia. Distinction between lymphocytic and myeloid forms of acute leukaemia in routine statistics has only been possible since 1968. There is no adequate study on the aetiology of acute lymphocytic leukaemia in adults. Apart from ionizing radiation and certain genetic conditions, risk factors for ALL are poorly understood. While Greaves' biological hypothesis offers some insight into childhood ALL, the causes of adult ALL are obscure. An epidemiological study of adult ALL is proposed, with particular emphasis on environmental risk factors and recent biological markers of ALL, in order to advance understanding of this leukaemia.
急性淋巴细胞白血病(ALL)的发病年龄呈双峰分布。它占儿童白血病诊断病例的大多数,但在成人白血病中所占比例不到5%。自1968年起,在常规统计中才能够区分急性白血病的淋巴细胞型和髓细胞型。目前尚无关于成人急性淋巴细胞白血病病因的充分研究。除了电离辐射和某些遗传条件外,ALL的危险因素知之甚少。虽然格里夫斯的生物学假说为儿童ALL提供了一些见解,但成人ALL的病因仍不清楚。本文提出对成人ALL进行一项流行病学研究,特别关注环境危险因素和ALL的最新生物学标志物,以增进对这种白血病的了解。