大鼠肝脏微粒体对N-亚硝基哌啶代谢中的α-羟基化作用：5-羟基戊醛的形成。
Alpha-hydroxylation in the metabolism of N-nitrosopiperidine by rat liver microsomes: formation of 5-hydroxypentanal.
作者信息
Leung K H, Park K K, Archer M C
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Feb;19(2):201-11.
PMID:148095
Abstract
Metabolism of n-nitrosopiperidine by a purified microsomal preparation from rat liver was shown to yield 5-hydroxypentanal. This is the predicted product for a pathway involving an initial oxidation of the nitrosamine at the carbon atom alpha to the nitroso group.
摘要
大鼠肝脏纯化微粒体制剂对N-亚硝基哌啶的代谢显示会产生5-羟基戊醛。这是一条涉及亚硝胺在亚硝基碳原子α位发生初始氧化途径的预测产物。
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