Preussmann R
Naturwissenschaften. 1984 Jan;71(1):25-30. doi: 10.1007/BF00365976.
A short review is given on the potent and organ-specific carcinogenic effects of N-nitroso compounds. Like many other chemical carcinogens, nitrosamino compounds require activation in vivo via enzymatic alpha-hydroxylation to form alkylating agents as ultimate carcinogens. Since no epidemiological data in man are available, extrapolation of animal data to man are important as well as dose-response studies in risk evaluations. Important aspects of these problems are presented. Finally the environmental impact of N-nitroso compounds is summarized.
本文简要综述了N-亚硝基化合物的强致癌作用及器官特异性致癌效应。与许多其他化学致癌物一样，亚硝胺化合物需要在体内通过酶促α-羟基化作用激活，以形成烷基化剂作为最终致癌物。由于缺乏人类流行病学数据，在风险评估中，将动物数据外推至人类以及进行剂量反应研究都很重要。文中介绍了这些问题的重要方面。最后总结了N-亚硝基化合物对环境的影响。
