Mims C A
Department of Microbiology, Guys Hospital Medical School, London, UK.
Vet Microbiol. 1992 Nov;33(1-4):5-12. doi: 10.1016/0378-1135(92)90030-w.
Interesting recent highlights into the pathogenesis of viral infections have come from: (1) Studies of viruses that persist in cells and modify cell function without causing cell damage. (2) Transgenic mouse studies showing how tissue-specific transcriptional activators control virus expression and can determine viral tropism. (3) Studies of the influence of cell differentiation on viral expression. (4) The exploding world of cytokines, whose baffling complexity and multiple interactions are subjects of intense study. (5) Studies of the interaction of viruses with the immune system. In each case, no molecular studies are giving unprecedented insights into disease processes. However, even when viral genomes are sequenced and virulence genes identified there are additional daunting steps before we understand the role of a given gene product in pathogenesis.
（1）对那些在细胞中持续存在并改变细胞功能而不引起细胞损伤的病毒的研究。（2）转基因小鼠研究表明组织特异性转录激活因子如何控制病毒表达并能决定病毒嗜性。（3）细胞分化对病毒表达影响的研究。（4）细胞因子这个迅速发展的领域，其令人困惑的复杂性和多重相互作用是深入研究的课题。（5）病毒与免疫系统相互作用的研究。在每种情况下，分子研究都为疾病过程提供了前所未有的见解。然而，即使对病毒基因组进行了测序并鉴定出毒力基因，在我们了解特定基因产物在发病机制中的作用之前，仍有其他艰巨的步骤。
