病毒性疾病发病机制中的免疫机制：综述
Immune mechanisms in the pathogenesis of viral diseases: a review.
作者信息
Trautwein G
机构信息
Department of Pathology, School of Veterinary Medicine, Hannover, Germany.
出版信息
Vet Microbiol. 1992 Nov;33(1-4):19-34. doi: 10.1016/0378-1135(92)90032-o.
Three immunopathological mechanisms may determine the pathogenesis of viral diseases in animals. (1) A variety of viruses causes transient or prolonged immunosuppression by infecting lymphoreticular tissues and interacting with components of the immune system. (2) In persistent viral infections effective immune responses may result in tissue damage. The mechanisms involved are T-cell-mediated destruction of infected cells and delayed-type hypersensitivity. (3) In a number of viral diseases pathogenic immune complexes are formed when antibodies are produced and react with viral antigen molecules persisting in the host. The selected examples of immune dysfunction are the focus of this review.
三种免疫病理机制可能决定动物病毒性疾病的发病机制。（1）多种病毒通过感染淋巴网状组织并与免疫系统成分相互作用，导致短暂或长期的免疫抑制。（2）在持续性病毒感染中，有效的免疫反应可能导致组织损伤。涉及的机制是T细胞介导的受感染细胞的破坏和迟发型超敏反应。（3）在许多病毒性疾病中，当产生抗体并与宿主中持续存在的病毒抗原分子反应时，会形成致病性免疫复合物。免疫功能障碍的选定例子是本综述的重点。
Zotero 插件