Presterl E, Bognar H, Winkler S, Thalhammer F, Georgopoulos A, Hoffmann W, Breyer S
Klinischen Abteilung für Infektionen und Chemotherapie, Universitätsklinik für Innere Medizin I, Wien.
Wien Med Wochenschr. 1992;142(17):381-5.
125 hospitalized patients (56 men and 69 women) suffering from urinary tract infection (UTI) and 15 women with endometritis or pelvic inflammatory disease were treated with ofloxacin 6 mg/kg/d i.v. divided into 2 doses. Two thirds of the patients were switched to oral ofloxacin using the same dose regimen after 4 days. The median duration of treatment was 10 days. 98 patients were evaluable for efficacy: 45 had complicated lower UTI, 32 had upper UTI (75% of them with complications), 13 had endometritis and 8 an uncomplicated lower UTI. The most frequent complications of UTI were: obstruction (n = 27), indwelling catheters (n = 23), urinary concrements (n = 12), residual urine (n = 8) and a neurogenic bladder (n = 6). 22 patients had diabetes mellitus. A total of 103 pathogens was isolated from the urine of 85 patients, the most frequent being E. coli, Proteus spp. and Enterococcus faecalis. 98% of patients with UTI and 85% of patients with endometritis were clinically cured. Adverse drug events were observed in 6 patients.
125例患有尿路感染（UTI）的住院患者（56名男性和69名女性）以及15例患有子宫内膜炎或盆腔炎的女性接受了静脉注射氧氟沙星治疗，剂量为6mg/kg/天，分2次给药。三分之二的患者在4天后改用相同剂量方案的口服氧氟沙星。治疗的中位持续时间为10天。98例患者可评估疗效：45例患有复杂性下尿路感染，32例患有上尿路感染（其中75%伴有并发症），13例患有子宫内膜炎，8例患有非复杂性下尿路感染。尿路感染最常见的并发症为：梗阻（n = 27）、留置导管（n = 23）、尿路结石（n = 12）、残余尿（n = 8）和神经源性膀胱（n = 6）。22例患者患有糖尿病。共从85例患者的尿液中分离出103种病原体，最常见的是大肠杆菌、变形杆菌属和粪肠球菌。98%的尿路感染患者和85%的子宫内膜炎患者临床治愈。6例患者观察到药物不良事件。
