癫痫中的认知：一项多通道事件相关电位（P300）研究。

Cognition in epilepsy: a multichannel event related potential (P300) study.

作者信息

Triantafyllou N I, Zalonis I, Kokotis P, Anthracopoulos M, Siafacas A, Malliara S, Hamburger H L, Papageorgiou C

机构信息

Neurological Clinic, Athens University, Eginition Hospital, Greece.

出版信息

Acta Neurol Scand. 1992 Nov;86(5):462-5. doi: 10.1111/j.1600-0404.1992.tb05124.x.

DOI:10.1111/j.1600-0404.1992.tb05124.x

PMID:1481627

Abstract

Auditory event-related potentials (AERP) were elicited in 68 epileptic patients and 30 age-matched controls. Epileptic patients had significantly prolonged N2 and P300 (P3) latencies compared with controls. Seven patients were above the range of 3 standard deviations from the control mean values. Amongst epileptics, patients with temporal lobe epilepsy had significantly prolonged P3 latencies compared to patients with idiopathic generalized epilepsy. Patients with abnormal EEGs had significantly prolonged P3 latencies compared to those with normal EEGs. Patients on anticonvulsant monotherapy had shorter P3 latencies, compared to patients taking a combination of two or more anticonvulsants. Patients on shorter duration of treatment had less prolonged P3 latencies compared to those on longer anticonvulsant treatment.

摘要

对68例癫痫患者和30例年龄匹配的对照者进行了听觉事件相关电位（AERP）检测。与对照组相比，癫痫患者的N2和P300（P3）潜伏期显著延长。7例患者超出对照均值3个标准差范围。在癫痫患者中，颞叶癫痫患者的P3潜伏期比特发性全身性癫痫患者显著延长。脑电图异常的患者比脑电图正常的患者P3潜伏期显著延长。与服用两种或更多种抗惊厥药物联合治疗的患者相比，接受抗惊厥单药治疗的患者P3潜伏期较短。治疗时间较短的患者与接受较长时间抗惊厥治疗的患者相比，P3潜伏期延长较少。