儿童癫痫患者P300潜伏期随年龄的变化
Changes of P300 latency with age in childhood epilepsy.
作者信息
Konishi T, Naganuma Y, Hongou K, Murakami M, Yamatani M, Yagi S
机构信息
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
出版信息
Pediatr Neurol. 1995 Feb;12(2):132-5. doi: 10.1016/0887-8994(95)00001-v.
Auditory event-related potentials (P300 latency; odd-ball paradigm) were examined in 129 patients with childhood epilepsies and 53 controls. The P300 latency in the patients with epilepsies (373 +/- 39.4 ms) was significantly longer than in controls (356 +/- 38.4), and the prolongation was greatest in the patients with symptomatic partial epilepsies (390 +/- 40.5), mild in those with idiopathic generalized epilepsies (370 +/- 24.3), and minimum in those with idiopathic partial epilepsies (363 +/- 28.9). Abnormal P300 latency occurred at all ages during childhood in patients with symptomatic partial epilepsies, and at older ages in patients with idiopathic generalized epilepsies. The shortening of latency with age was relatively small in patients with epilepsies compared with controls. These results suggest that the prolongation of P300 latency (i.e., existence of cognitive disturbance) displays characteristic changes with age in each epileptic syndrome.
对129例儿童癫痫患者和53名对照者进行了听觉事件相关电位检查（P300潜伏期；Odd - ball范式）。癫痫患者的P300潜伏期（373±39.4毫秒）显著长于对照组（356±38.4毫秒），且症状性部分性癫痫患者的延长最为明显（390±40.5毫秒），特发性全身性癫痫患者的延长程度较轻（370±24.3毫秒），特发性部分性癫痫患者的延长程度最小（363±28.9毫秒）。症状性部分性癫痫患者在儿童期各年龄段均出现P300潜伏期异常，特发性全身性癫痫患者则在较大年龄出现异常。与对照组相比，癫痫患者潜伏期随年龄的缩短相对较小。这些结果表明，P300潜伏期的延长（即存在认知障碍）在每种癫痫综合征中均随年龄呈现出特征性变化。
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