日本最北端岛屿北海道多发性硬化症的人类白细胞抗原谱。

HLA profiles of multiple sclerosis in Hokkaido, the northernmost island of Japan.

作者信息

Fukazawa T, Hamada T, Tashiro K, Moriwaka F, Yanagihara T, Sugiyama K, Tsukada Y

机构信息

Hokuyukai Neurological Hospital, Sapporo, Japan.

出版信息

Acta Neurol Scand. 1992 Nov;86(5):517-20. doi: 10.1111/j.1600-0404.1992.tb05135.x.

DOI:10.1111/j.1600-0404.1992.tb05135.x

PMID:1481634

Abstract

We studied HLA haplotypes in 43 consecutive clinically definite MS patients in Hokkaido. The patients were classified into Group A, 12 patients with acute transverse myelopathy (ATM) during the course of illness, and Group B, 31 without ATM. We found an association with HLA-DQw7 in Group A, and with DR4 and DRw8 in Group B. The frequency of DQw7 and DR4 were significantly different between Groups A and B. This study may indicate the different genetic backgrounds between the groups. DRw8 and DRw52 antigens were significantly more common in MS than in controls. Our result is inconsistent with previous Japanese studies, and ethnic variation might be considered as a possible cause of the contradiction.

摘要

我们对北海道43例连续的临床确诊多发性硬化症患者的HLA单倍型进行了研究。患者被分为A组，12例在病程中出现急性横贯性脊髓炎（ATM）的患者，以及B组，31例无ATM的患者。我们发现A组与HLA - DQw7相关，B组与DR4和DRw8相关。A组和B组之间DQw7和DR4的频率有显著差异。这项研究可能表明两组之间存在不同的遗传背景。DRw8和DRw52抗原在多发性硬化症患者中比在对照组中明显更常见。我们的结果与之前的日本研究不一致，种族差异可能被认为是造成这种矛盾的一个可能原因。