Niwa T, Miyazaki T, Hashimoto N, Hayashi H, Ise M, Uehara Y, Maeda K
Department of Internal Medicine, Nagoya University Branch Hospital, Japan.
Am J Nephrol. 1992;12(4):201-6. doi: 10.1159/000168447.
In uremic patients, the serum concentration of indoxyl sulfate is markedly increased. To determine if oral sorbent (AST-120) suppresses the endogenous synthesis of indoxyl sulfate, it was administered to experimental uremic rats, and the serum concentration and urinary excretion of indoxyl sulfate were quantified by high-performance liquid chromatography. Oral sorbent decreased both the serum concentration and urinary excretion of indoxyl sulfate, suggesting that there was suppression of the endogenous synthesis of indoxyl sulfate by the oral sorbent. Oral sorbent did not decrease the serum concentration and urinary excretion of hippuric acid, but it did alleviate the deterioration of renal function in the experimental uremic rats.
在尿毒症患者中，硫酸吲哚酚的血清浓度显著升高。为了确定口服吸附剂（AST - 120）是否抑制硫酸吲哚酚的内源性合成，将其给予实验性尿毒症大鼠，并通过高效液相色谱法定量测定硫酸吲哚酚的血清浓度和尿排泄量。口服吸附剂降低了硫酸吲哚酚的血清浓度和尿排泄量，表明口服吸附剂抑制了硫酸吲哚酚的内源性合成。口服吸附剂并未降低马尿酸的血清浓度和尿排泄量，但确实缓解了实验性尿毒症大鼠肾功能的恶化。
