Cridland R A, Kasting N W
Department of Physiology, University of British Columbia, Vancouver, Canada.
Am J Physiol. 1992 Dec;263(6 Pt 2):R1235-40. doi: 10.1152/ajpregu.1992.263.6.R1235.
Previous investigations on the antipyretic properties of arginine vasopressin have used bacterial endotoxins or pyrogens to induce fever. Because these experimental models of fever fail to mimic all aspects of the responses to infection, we felt it was important to examine the role of endogenously released vasopressin as a neuromodulator in febrile thermoregulation during infection. Therefore the present study examines the effects of chronic infusion of a V1-receptor antagonist or saline (via osmotic minipumps into the ventral septal area of the brain) on a fever induced by injection of live bacteria. Telemetry was used for continuous measurement of body temperature in the awake unhandled rat. Animals infused with the V1-antagonist exhibited fevers that were greater in duration compared with those of saline-infused animals. These results support the hypothesis that vasopressin functions as an antipyretic agent or fever-reducing agent in brain. Importantly, they suggest that endogenously released vasopressin may play a role as a neuromodulator in natural fever.
先前关于精氨酸加压素解热特性的研究使用细菌内毒素或致热原诱导发热。由于这些发热实验模型无法模拟感染反应的所有方面，我们认为研究内源性释放的加压素作为神经调节剂在感染期间发热性体温调节中的作用很重要。因此，本研究考察了慢性输注V1受体拮抗剂或生理盐水（通过渗透微型泵注入脑腹侧隔区）对注射活细菌诱导的发热的影响。采用遥测技术连续测量清醒未处理大鼠的体温。与输注生理盐水的动物相比，输注V1拮抗剂的动物发热持续时间更长。这些结果支持了加压素在大脑中作为解热剂或退热剂发挥作用的假说。重要的是，它们表明内源性释放的加压素可能在自然发热中作为神经调节剂发挥作用。
