Veale W L, Cooper K E, Ruwe W D
Brain Res Bull. 1984 Feb;12(2):161-5. doi: 10.1016/0361-9230(84)90184-9.
When pyrogenic substances are injected intravenously into experimental animals, a sequence of events is set in motion which involves the hypothalamus and perhaps other portions of the diencephalon to produce a febrile response. We now present evidence that the brain produces its own endogenous antipyretic which may serve as a means of controlling the extent of the fever. When arginine vasopressin is perfused through the lateral septal area of the hypothalamus of the sheep, fever is suppressed. Vasopressin alone does not lower normal body temperature when perfused through this region of the brain. In addition, evidence is provided to indicate that vasopressin is released within the lateral septal area during the febrile response. It is concluded that, in fever, arginine vasopressin may be released in the lateral septal area of the brain and serve as an endogenous antipyretic. Results indicate that, following an initial application of vasopressin into the brain itself, a subsequent similar administration of vasopressin produces seizure-like activity. Therefore, it is suggested that this release of arginine vasopressin may contribute to the production of febrile convulsion.
当将致热物质静脉注射到实验动物体内时，一系列事件就会启动，这涉及下丘脑以及间脑的其他部分，从而产生发热反应。我们现在提供证据表明，大脑会产生自身的内源性解热物质，这可能是控制发热程度的一种方式。当精氨酸加压素灌注到绵羊下丘脑的外侧隔区时，发热会受到抑制。单独灌注加压素通过该脑区时不会降低正常体温。此外，有证据表明在发热反应期间加压素会在外侧隔区内释放。得出的结论是，在发热时，精氨酸加压素可能在脑的外侧隔区释放，并作为内源性解热物质起作用。结果表明，在首次将加压素应用于脑本身之后，随后再次给予类似剂量的加压素会产生癫痫样活动。因此，有人提出精氨酸加压素的这种释放可能导致热性惊厥的发生。
