Korsager S, Chatham E M, Ostergaard Kristensen H P
Acta Endocrinol (Copenh). 1978 May;88(1):48-54. doi: 10.1530/acta.0.0880048.
Thyroid status was studied in 24 patients above the age of 40 years with Down's syndrome. Three patients had thyroid function tests indicating hypothyroidism. Eight patients had thyroid autoantibodies in serum and 8 patients had a higher than normal level of thyroid stimulating hormone in serum. None of the patients had figures indicating thyrotoxicosis. None of the patients showed any of the clinical signs usually seen in patients with hypothyroidism. It is concluded that biochemical tests indicating hypothyroidism are much more often seen in patients with Down's syndrome than in normal subjects and that thyroid status should be assessed in old patients with this disease.
对24例40岁以上的唐氏综合征患者的甲状腺状况进行了研究。3例患者的甲状腺功能测试显示甲状腺功能减退。8例患者血清中有甲状腺自身抗体，8例患者血清中促甲状腺激素水平高于正常。没有患者的指标表明存在甲状腺毒症。没有患者表现出通常在甲状腺功能减退患者中出现的任何临床体征。结论是，与正常受试者相比，唐氏综合征患者中更常出现表明甲状腺功能减退的生化检查结果，并且应该对患有这种疾病的老年患者的甲状腺状况进行评估。
