Agarwal A
Division of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Arch Androl. 1992 Nov-Dec;29(3):207-13. doi: 10.3109/01485019208987726.
The purpose of this study is to review our experience with sperm washing and intrauterine insemination as a method to reduce the presence of sperm antibodies in serum of couples with immunological infertility. Our results support the premise that sperm washing and intrauterine insemination can diminish the level of sperm-bound immunoglobulins and can improve the chance of conception in a selected group of couples with a diagnosis of immunological infertility. Patients with > 50% attachment of IgG, IgA, or both antisperm antibodies in this study had a greater chance of achieving a pregnancy. The high level of antibody attachment seen in our study appears to represent true immunological infertility and therefore is more likely to respond to therapy that reduces antibody attachment and bypasses cervical mucus.
本研究的目的是回顾我们将精子洗涤和宫腔内人工授精作为一种减少免疫性不孕夫妇血清中精子抗体存在的方法的经验。我们的结果支持这样一个前提，即精子洗涤和宫腔内人工授精可以降低精子结合免疫球蛋白的水平，并可以提高一组经诊断为免疫性不孕夫妇的受孕几率。在本研究中，IgG、IgA或两者抗精子抗体附着率>50%的患者受孕几率更大。我们研究中观察到的高抗体附着水平似乎代表真正的免疫性不孕，因此更有可能对减少抗体附着并绕过宫颈黏液的治疗产生反应。
