Confino E, Friberg J, Dudkiewicz A B, Gleicher N
Fertil Steril. 1986 Jul;46(1):55-60.
The success of intrauterine inseminations with washed human spermatozoa was evaluated in four groups of patients. The first two groups were couples in whom either the man or the woman had detectable circulating sperm-agglutinating antibodies. The third group included couples where the woman exhibited hostile or absent cervical mucus, whereas the fourth group represented couples with oligozoospermic males. The couples underwent 3.7 +/- 2.1 insemination cycles, with a 30% overall pregnancy rate for all four groups. Intrauterine inseminations of women with hostile cervical mucus yielded a 68% conception rate. Couples with either male or female serum sperm-agglutinating antibodies showed 25% and 40% pregnancy rates, respectively. However, none of the couples with oligozoospermic males achieved pregnancy. Intrauterine inseminations with washed human spermatozoa thus represent a satisfactory method of achieving pregnancy in women with hostile cervical mucus and in couples with circulating sperm agglutinating antibodies. Couples in whom oligozoospermia has been identified as the principal cause of infertility do not seem to benefit from this therapy.
对四组患者评估了使用洗涤过的人类精子进行宫内人工授精的成功率。前两组是夫妻，其中男方或女方体内可检测到循环精子凝集抗体。第三组包括女方宫颈黏液呈敌对性或缺乏的夫妻，而第四组代表男方为少精子症的夫妻。这些夫妻接受了3.7±2.1个授精周期，四组总体妊娠率为30%。宫颈黏液呈敌对性的女性进行宫内人工授精的受孕率为68%。男方或女方血清中有精子凝集抗体的夫妻，妊娠率分别为25%和40%。然而，男方为少精子症的夫妻均未受孕。因此，使用洗涤过的人类精子进行宫内人工授精是使宫颈黏液呈敌对性的女性以及体内有循环精子凝集抗体的夫妻受孕的一种令人满意的方法。已确定少精子症为主要不孕原因的夫妻似乎无法从这种治疗中获益。
