Küchle M, Schönherr U, Nguyen N X, Steinhäuser B, Naumann G O
Abteilungen für Augenheilkunde, Universität Erlangen-Nürnberg, Federal Republic of Germany.
Ger J Ophthalmol. 1992;1(3-4):164-9.
In order to evaluate the applicability of the laser flare-cell meter to diabetic oculopathy, we measured aqueous flare and aqueous "cells" in 84 diabetic eyes of 84 patients and 50 normal control eyes of 50 age-matched subjects. Using fluorescein angiography, diabetic retinopathy was divided into background retinopathy (11 eyes), preproliferative retinopathy (38 eyes), and proliferative retinopathy (35 eyes). In diabetic eyes, the occurrence of both aqueous flare (0.73 +/- 0.39 mg/ml human albumin equivalent) and aqueous cells (mean 2.96, range 0-35.7 cells/0.075 mm3) was significantly greater than in the normal control group (flare 0.14 +/- 0.06 mg/ml, cells 0.39, range 0-2 cells/0.075 mm3, P < 0.0001 and P < 0.0002, respectively). The flare values also showed differences between the diabetic subgroups, with flare values being higher in more advanced stages of diabetic retinopathy. No significant correlation could be found between the flare values and the kind of diabetic therapy, the duration of the diabetes, and the number of or the time interval since previous retinal laser coagulations. A flare value of more than 0.5 mg/ml was found to represent probably a "critical value" indicating a tendency towards preproliferative and or proliferative changes. The laser flare-cell meter is a valuable instrument for noninvasive, quantitative assessment of alterations of the blood-aqueous barrier in diabetes. The increase of flare values seems to parallel the progression of diabetic retinopathy.
为了评估激光散射细胞仪在糖尿病眼病中的适用性，我们对84例患者的84只糖尿病眼和50例年龄匹配的正常对照者的50只眼进行了房水闪光和房水“细胞”测量。通过荧光素血管造影，将糖尿病视网膜病变分为背景性视网膜病变（11只眼）、增殖前期视网膜病变（38只眼）和增殖性视网膜病变（35只眼）。糖尿病眼中房水闪光（0.73±0.39mg/ml人白蛋白当量）和房水细胞（平均2.96，范围0 - 35.7个细胞/0.075mm³）的出现率均显著高于正常对照组（闪光0.14±0.06mg/ml，细胞0.39，范围0 - 2个细胞/0.075mm³，P分别<0.0001和P<0.0002）。闪光值在糖尿病亚组之间也存在差异，在糖尿病视网膜病变更晚期阶段闪光值更高。在闪光值与糖尿病治疗类型、糖尿病病程、既往视网膜激光光凝的次数或时间间隔之间未发现显著相关性。发现闪光值大于0.5mg/ml可能代表一个“临界值”，表明有增殖前期和/或增殖性改变的倾向。激光散射细胞仪是一种用于无创、定量评估糖尿病患者血-房水屏障改变的有价值的仪器。闪光值的增加似乎与糖尿病视网膜病变的进展平行。
