Küchle M, Nguyen N X, Naumann G O
Universitäts-Augenklinik mit Poliklinik Erlangen-Nürnberg.
Ophthalmologe. 1994 Apr;91(2):219-23.
The laser flare-cell meter (LFCM) allows noninvasive, quantitative measurement of aqueous flare in human eyes. In this study we analysed changes in aqueous flare in eyes with various forms of intraocular inflammations. PATIENTS. We examined 100 eyes of 100 patients aged (mean +/- SD) 40.2 +/- 19.8 years with acute and chronic intraocular inflammations. The inflammatory diseases were classified according to morphological criteria. In addition, 163 normal eyes of 163 subjects (mean age 44.8 +/- 17.9 years) were evaluated. The eyes were examined by three examiners using the LFCM (Kowa, FC-1000) after pupillary dilatation with mydriatics. The instrument was calibrated with standardized concentrations of human albumin concentrations, and flare values were transformed into human albumin concentration equivalents. For statistical analysis, the non-parametric Wilcoxon-Mann-Whitney test was used. RESULTS. Flare values (mean +/- SD) in the eyes with intraocular inflammations were 4.38 +/- 11.82 mg/ml human albumin equivalents and were significantly higher than in the group of normal eyes (0.11 +/- 0.06 mg/ml, P < 0.0001). In addition, flare values differed in the various inflammation groups, with human albumin concentration equivalents decreasing in the following order: acute iridocyclitis (n = 27, 10.81 +/- 21.12), chronic iridocyclitis (n = 19, 5.19 +/- 6.12), necrotizing retinitis (n = 6, 1.92 +/- 1.11), acute retinochoroiditis (n = 9, 1.46 +/- 2.35), retinal vasculitis (n = 24, 1.03 +/- 0.90), chorioretinitis (n = 5, 0.98 +/- 0.71), Fuchs' uveitis (n = 10, 0.52 +/- 0.25). CONCLUSION. Measurement of aqueous flare with the LFCM is a noninvasive examination that yields objective, quantitative and reproducible results and therefore has advantages over slit-lamp assessment. It gives valuable information about the integrity or impairment of the blood-aqueous barrier. Its possible clinical applications include follow-up examinations and "monitoring" of therapeutic regimens in uveitis.
激光闪光细胞仪（LFCM）可对人眼房水闪光进行无创定量测量。在本研究中，我们分析了各种形式眼内炎症患者眼房水闪光的变化。患者。我们检查了100例年龄（平均±标准差）为40.2±19.8岁的急性和慢性眼内炎症患者的100只眼睛。根据形态学标准对炎症性疾病进行分类。此外，还评估了163名受试者（平均年龄44.8±17.9岁）的163只正常眼睛。在使用散瞳剂散瞳后，由三名检查人员使用LFCM（Kowa，FC - 1000）对眼睛进行检查。该仪器用标准化人白蛋白浓度进行校准，闪光值被转换为人白蛋白浓度当量。统计学分析采用非参数Wilcoxon - Mann - Whitney检验。结果。眼内炎症患者眼睛的闪光值（平均±标准差）为4.38±11.82mg/ml人白蛋白当量，显著高于正常眼组（0.11±0.06mg/ml，P < 0.0001）。此外，不同炎症组的闪光值有所不同，人白蛋白浓度当量按以下顺序降低：急性虹膜睫状体炎（n = 27，10.81±21.12）、慢性虹膜睫状体炎（n = 19，5.19±6.12）、坏死性视网膜炎（n = 6，1.92±1.11）、急性视网膜脉络膜炎（n = 9，1.46±2.35）、视网膜血管炎（n = 24，1.03±0.90）、脉络膜视网膜炎（n = 5，0.98±0.71）、富克斯葡萄膜炎（n = 10，0.52±0.25）。结论。使用LFCM测量房水闪光是一种无创检查，可得出客观、定量且可重复的结果，因此优于裂隙灯评估。它能提供有关血 - 房水屏障完整性或损害情况的有价值信息。其可能的临床应用包括葡萄膜炎治疗方案的随访检查和“监测”。
