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炭疽免疫研究。II. 炭疽芽孢杆菌非蛋白水解突变体在体外产生保护性抗原

Studies on immunity in anthrax. II. In vitro elaboration of protective antigen by non-proteolytic mutants of Bacillus anthracis.

作者信息

WRIGHT G G, HEDBERG M A, FEINBERG R J

出版信息

J Exp Med. 1951 Jun;93(6):523-7. doi: 10.1084/jem.93.6.523.

DOI:10.1084/jem.93.6.523
PMID:14832399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2136072/
Abstract

Non-proteolytic mutants were isolated from the Vollum strain of B. anthracis following ultraviolet treatment. The mutants were virulent for rabbits and mice and their non-proteolytic character was stable in culture and on serial passage in rabbits. The mutants produced protective antigen under suitable conditions of cultivation in vitro, and allowed longer incubation of the cultures without destruction of the protective antigen than did the parent strain. The meaning of the results is discussed.

摘要

经紫外线处理后，从炭疽芽孢杆菌沃勒姆菌株中分离出非蛋白水解突变体。这些突变体对兔和小鼠具有毒性，且其非蛋白水解特性在培养过程以及在兔体内连续传代时保持稳定。这些突变体在体外合适的培养条件下产生保护性抗原，并且与亲本菌株相比，在不破坏保护性抗原的情况下，培养物的孵育时间更长。对结果的意义进行了讨论。

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本文引用的文献

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A PROTEOLYTIC ENZYME PRODUCED BY GROUP A STREPTOCOCCI WITH SPECIAL REFERENCE TO ITS EFFECT ON THE TYPE-SPECIFIC M ANTIGEN.A 族链球菌产生的一种蛋白水解酶，特别针对其对型特异性 M 抗原的影响。
J Exp Med. 1945 Jun 1;81(6):573-92. doi: 10.1084/jem.81.6.573.
2
Studies on infection with Bacillus anthracis; the production of an immunizing antigen in vitro.炭疽芽孢杆菌感染的研究；体外免疫抗原的产生。
J Infect Dis. 1949 Jan-Feb;84(1):92-7. doi: 10.1093/infdis/84.1.92.