卡介苗菌株（卡尔梅特-介朗杆菌）的变异性
Variability of BCG strains (Bacillus Calmette-Guérin).
作者信息
SUTER W E, DUBOS R J
出版信息
J Exp Med. 1951 Jun;93(6):559-72. doi: 10.1084/jem.93.6.559.
Abstract
Three different cultures of BCG propagated for over 2 years in a liquid medium containing Tween 80 and albumin were found to differ in several of their intrinsic properties. Cultures of the three strains were found to consist of morphologically heterogeneous populations-each culture being made up of three main colonial types-spreading, intermediate, and non-spreading. The percentage distribution of colonial types was characteristic for each culture and remained constant during cultivation in liquid media. Injection of the various cultures into mice and guinea pigs resulted in a self-limited disease. The distribution, extent, and duration of the lesions were also characteristic for each culture. Both the spreading and non-spreading substrains derived from the various cultures exhibited the degree of attenuation of virulence characteristic of the parent strain.
摘要
在含有吐温80和白蛋白的液体培养基中繁殖超过2年的三种不同卡介苗培养物，其若干内在特性存在差异。发现这三种菌株的培养物由形态学上异质的群体组成——每种培养物由三种主要菌落类型组成，即扩散型、中间型和非扩散型。菌落类型的百分比分布对每种培养物而言具有特征性，并且在液体培养基中培养期间保持恒定。将各种培养物注射到小鼠和豚鼠体内会导致一种自限性疾病。病变的分布、范围和持续时间对每种培养物来说也具有特征性。源自各种培养物的扩散型和非扩散型亚菌株均表现出亲代菌株特有的毒力减弱程度。
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