Jensen H S
Department of Rheumatology TTA, Rigshospitalet University Hospital, Copenhagen, Denmark.
Clin Exp Rheumatol. 1992 Nov-Dec;10(6):607-12.
Activation of human monocytes in rheumatic disorders includes the production of substances active in immunologic interactions, inflammatory responses, and tissue remodelling. This review discusses the cell surface-related elastolytic activity of live human monocytes, as determined by a newly developed elastin assay. Elastase activity was not found to be depressed by patient treatment with glucocorticoids or slow-acting disease modifying drugs nor enhanced by phagocytosis, but was increased by immune complexes in vitro and in patients with rheumatoid arthritis or giant cell arteritis. The leucocyte elastase content seems to be influenced by systemic factors before the monocytes are released into the blood. The enzyme expression of elastase is determined by local factors acting after the cells have left the circulation. Monocyte expression may therefore be a link between immune activation and proteolytic activity.
风湿性疾病中人类单核细胞的激活包括产生在免疫相互作用、炎症反应和组织重塑中具有活性的物质。本综述讨论了通过新开发的弹性蛋白测定法所确定的活的人类单核细胞的细胞表面相关弹性溶解活性。未发现糖皮质激素或慢作用抗风湿药治疗患者会降低弹性蛋白酶活性，吞噬作用也不会增强该活性，但在体外以及类风湿关节炎或巨细胞动脉炎患者体内，免疫复合物会使其增加。在单核细胞释放到血液之前，白细胞弹性蛋白酶含量似乎受全身因素影响。弹性蛋白酶的酶表达由细胞离开循环后起作用的局部因素决定。因此，单核细胞表达可能是免疫激活与蛋白水解活性之间的一个环节。
