Jensen H S, Mogensen H H, Mikkelsen A G
Department of Medicine F, Gentofte University Hospital, Copenhagen, Denmark.
Scand J Rheumatol. 1990;19(4):251-6. doi: 10.3109/03009749009102531.
The elastolytic capacity of live human blood monocytes was studied in patients with giant cell arteritis (GA) and in age-matched controls. Despite normalized acute-phase reactants during glucocorticoid (GC) therapy, the basic activity of monocytes from patients with newly diagnosed GA was elevated compared with controls (80 vs. 39 ng/h, p less than or equal to 0.01). The maximum response was enhanced by stimulation with immune complexes (224 vs. 125 ng/h, p less than or equal to 0.01) and with phorbol myristic acetate (324 vs. 214 ng/h, p less than or equal to 0.01). No age difference was found between healthy young and old people. Cell surface related human monocyte elastolytic activity could act as a sensitive marker of cell activation in vivo.
在巨细胞动脉炎（GA）患者和年龄匹配的对照组中研究了活人血液单核细胞的弹性蛋白酶溶解能力。尽管在糖皮质激素（GC）治疗期间急性期反应物恢复正常，但新诊断的GA患者单核细胞的基础活性与对照组相比仍有所升高（80对39 ng/h，p≤0.01）。免疫复合物刺激（224对125 ng/h，p≤0.01）和佛波酯肉豆蔻酸酯刺激（324对214 ng/h，p≤0.01）可增强最大反应。健康年轻人和老年人之间未发现年龄差异。细胞表面相关的人类单核细胞弹性蛋白酶溶解活性可作为体内细胞活化的敏感标志物。
