Koppe J G, Olie K, van Wijnen J
Department of Neonatology, University of Amsterdam, The Netherlands.
Dev Pharmacol Ther. 1992;18(1-2):9-13.
Placental transport of dioxins and furans from mother to fetus takes place. It is probably related to the fatty acid transport. Between 10 and 20% of fatty acids in a full-term baby are of maternal origin. In adipose tissue of children that died in the early neonatal period concentrations of +/- 25% were found of three dioxin and furan congeners 12378 P5CDD, 123678 H6CDD, and 23478 P5CDF in relation to a mean concentration of these congeners in the fat of 14 breastmilk samples. Data of concentrations are given as measured in liver and adipose tissue. In the placenta of a Dutch woman an accumulation of dioxins and furans is found in relation to blood. Animal studies support the hypothesis that polychlorobifenyls play a role in the cause of the late hemorrhagic disease in the newborn, in particular the 2, 4, 5, 2, 4, 5-hexachlorobifenyl that is present in relatively high concentrations in breastmilk.
二噁英和呋喃会从母体经胎盘转运至胎儿体内。这可能与脂肪酸转运有关。足月婴儿体内10%至20%的脂肪酸来源于母体。在新生儿早期死亡儿童的脂肪组织中，相对于14份母乳样本脂肪中这三种二噁英和呋喃同系物（12378五氯二苯并二噁英、123678六氯二苯并二噁英和23478五氯二苯并呋喃）的平均浓度，发现其浓度有±25%的差异。浓度数据以在肝脏和脂肪组织中的测量值给出。在一名荷兰女性的胎盘中，发现二噁英和呋喃相对于血液有所蓄积。动物研究支持这样的假说，即多氯联苯在新生儿晚期出血性疾病的病因中起作用，尤其是母乳中相对高浓度存在的2,4,5,2,4,5-六氯联苯。
