Mendola P, Buck G M, Vena J E, Zielezny M, Sever L E
Department of Social and Preventive Medicine, State University of New York at Buffalo 14214, USA.
Environ Health Perspect. 1995 May;103(5):498-502. doi: 10.1289/ehp.95103498.
Spontaneous fetal death has been observed among various mammalian species after exposure to polychlorinated biphenyls (PCBs). Our exposure-based cohort study assessed the relationship between consumption of PCB-contaminated Lake Ontario sport fish and spontaneous fetal death using 1820 multigravid fertile women from the 1990-1991 New York State Angler Cohort Study. Fish consumption data were obtained from food frequency questionnaires and history of spontaneous fetal death from live birth certificates. Analyses were stratified by number of prior pregnancies and controlled for smoking and maternal age. No significant increases in risk for fetal death were observed across four measures of exposure: a lifetime estimate of PCB exposure based on species-specific PCB levels; the number of years of fish consumption; kilograms of sport fish consumed in 1990-1991; and a lifetime estimate of kilograms eaten. A slight risk reduction was seen for women with two prior pregnancies at the highest level of PCB exposure (odds ratio = 0.36; 95% CI, 0.14-0.92) and for women with three or more prior pregnancies with increasing years of fish consumption (odds ratio = 0.97; 95% CI, 0.94-0.99). These findings suggest that consumption of PCB-contaminated sport fish does not increase the risk of spontaneous fetal death.
在多种哺乳动物接触多氯联苯（PCBs）后，已观察到自发性胎儿死亡的情况。我们基于暴露的队列研究，利用1990 - 1991年纽约州垂钓者队列研究中的1820名多胎可育女性，评估了食用受多氯联苯污染的安大略湖食用鱼与自发性胎儿死亡之间的关系。鱼类消费数据来自食物频率问卷，自发性胎儿死亡史来自出生证明。分析按既往怀孕次数分层，并对吸烟和产妇年龄进行了控制。在四种暴露指标中，均未观察到胎儿死亡风险显著增加：基于特定物种多氯联苯水平的一生多氯联苯暴露估计值；鱼类消费年限；1990 - 1991年食用的食用鱼千克数；以及一生食用千克数的估计值。在多氯联苯暴露水平最高的情况下，有两次既往怀孕的女性出现了轻微的风险降低（比值比 = 0.36；95%可信区间，0.14 - 0.92），对于有三次或更多次既往怀孕且鱼类消费年限增加的女性也是如此（比值比 = 0.97；95%可信区间，0.94 - 0.99）。这些发现表明，食用受多氯联苯污染的食用鱼不会增加自发性胎儿死亡的风险。
