Ljubicić N, Bilić A, Plavsić V
Department of Gastroenterology and Hepatology, University of Zagreb, General Hospital, "Sveti Duh", Republic of Croatia.
Eur J Clin Pharmacol. 1992;43(5):555-8. doi: 10.1007/BF02285102.
The effect of propranolol on furosemide-stimulated urinary prostaglandin E2 (PGE2) excretion and renal blood flow was evaluated in 12 patients with alcoholic liver cirrhosis. Plasma and urine were collected before and 60 min after furosemide 20 mgI with or without propranolol pretreatment, and plasma renin activity (PRA), plasma aldosterone concentration (PAC), urinary excretion of PGE2 and sodium were determined. The renal interlobar arterial Pulsatility Index (PI), as an index of resistance to blood flow, was also determined before and 60 min after furosemide administration with and without propranolol pretreatment, by using a duplex Doppler ultrasound (Hitachi EUB 565). Urine volume and sodium excretion after furosemide administration were not influenced by the propranolol pretreatment. Furosemide administration significantly increased urinary PGE2 excretion, PRA and PAC, and these effects were significantly reduced by propranolol. Furosemide administration with or without propranolol significantly reduced renal interlobar arterial PI, the average reduction in PI being significantly lower after furosemide administration with propranolol pretreatment. The results demonstrate that propranolol pretreatment significantly influenced the furosemide-induced increase in urinary PGE2 excretion and renal interlobar arterial blood flow in cirrhotic patients.
在12例酒精性肝硬化患者中评估了普萘洛尔对速尿刺激的尿前列腺素E2（PGE2）排泄和肾血流量的影响。在给予20 mg速尿前及用药后60分钟采集血浆和尿液，速尿给药前或给药前给予普萘洛尔预处理，测定血浆肾素活性（PRA）、血浆醛固酮浓度（PAC）、PGE2和钠的尿排泄量。使用双功多普勒超声（日立EUB 565）在速尿给药前及给药后60分钟（有或无普萘洛尔预处理）测定肾叶间动脉搏动指数（PI），作为血流阻力指标。速尿给药后的尿量和钠排泄不受普萘洛尔预处理的影响。速尿给药显著增加尿PGE2排泄、PRA和PAC，而普萘洛尔可显著降低这些作用。速尿给药（有或无普萘洛尔）显著降低肾叶间动脉PI，普萘洛尔预处理后速尿给药时PI的平均降低幅度显著更低。结果表明，普萘洛尔预处理显著影响肝硬化患者速尿诱导的尿PGE2排泄增加和肾叶间动脉血流增加。
