Gogelia K, Hámori J
Beritashvili Institute of Physiology, Georgian Academy of Science, Tbilisi, Hungary.
Exp Brain Res. 1992;91(3):477-83. doi: 10.1007/BF00227843.
Numerical density and morphology of the two main GABAergic neuronal classes, the parvalbumin (PV) and calbindin- (CaBP)-containing nerve cells were investigated in long-term neocortical transplants in rats. It was observed that 4 months after the transplantation both CaBP- and PV-immunoreactive neurons survive and grow in neocortical grafts. However, the numerical density of PV cells decreased to about half of the control value (host cortex), while the density of CaBP-positive cells was 25-60% of that seen in the host cortex, depending on the degree of integration of the graft. The mean diameter of PV neurons rose to double of the control value, while the size of CaBP-positive perikarya did not change. This indicates that GABAergic neurons with hypertrophic perikarya (Bragin et al. 1991a) are identical to PV neurons. On the basis of these qualitative and quantitative morphological data it is concluded that PV- and CaBP-containing GABA cells in the transplant exhibit different sensitivities to transplantation-related structural and functional alterations.
在大鼠长期新皮质移植中，研究了两种主要的γ-氨基丁酸能（GABAergic）神经元类型，即含小白蛋白（PV）和含钙结合蛋白（CaBP）的神经细胞的数量密度和形态。观察到移植后4个月，含CaBP和PV免疫反应性神经元在新皮质移植物中存活并生长。然而，PV细胞的数量密度降至对照值（宿主皮质）的约一半，而CaBP阳性细胞的密度为宿主皮质中所见密度的25%-60%，这取决于移植物的整合程度。PV神经元的平均直径增至对照值的两倍，而CaBP阳性核周体的大小没有变化。这表明核周体肥大的GABA能神经元（Bragin等人，1991a）与PV神经元相同。基于这些定性和定量的形态学数据，可以得出结论，移植物中含PV和CaBP的GABA细胞对移植相关的结构和功能改变表现出不同的敏感性。
