Pawlicki R, Knychalska-Karwin Z, Stankiewicz D, Jakób-Dolezal K, Karwan T
Department of Histology, Institute of Pediatrics, Academy of Medicine, Kraków, Poland.
Folia Histochem Cytobiol. 1992;30(2):75-8.
Distribution of calcium and phosphorus was investigated with quantitative and qualitative methods in teeth of rats chronically treated with low doses of corticosteroids for 3 generations. In animals from 2nd and 3rd generation, scanning electron microscopy revealed focal lesions in enamel and dentin. The disturbances of the mineral metabolism in teeth of corticosteroid-treated rats were also reflected by abnormal calcium and phosphorus content in enamel and dentin, as assessed by X-ray microanalysis.
采用定量和定性方法，对连续3代长期接受低剂量皮质类固醇治疗的大鼠牙齿中的钙和磷分布进行了研究。在第二代和第三代动物中，扫描电子显微镜显示釉质和牙本质有局灶性病变。X射线微分析评估结果表明，皮质类固醇治疗的大鼠牙齿中矿物质代谢紊乱也表现为釉质和牙本质中钙和磷含量异常。
