Seyer-Hansen K
Diabetologia. 1978 May;14(5):325-8. doi: 10.1007/BF01223024.
The kidney growth seen after the induction of experimental diabetes in rats has been compared to the compensatory renal growth after one-sided nephrectomy. After five days the kidney weight had increased from 650 +/- 15 mg in a group of controls to 778 +/- 21 mg in diabetic rats, and 764 +/- 17 mg in unilaterally nephrectomised rats. The increased weight was in both groups reflected in an increased DNA content and increased RNA/DNA and protein/DNA ratios. In a group of rats made diabetic and nephrectomised at the same time, kidney weight increased to 953 +/- 22 mg after five days. When rats were unilaterally nephrectomised after 20 days of untreated diabetes, compensatory growth was much more pronounced than in non-diabetic rats, kidney weight rising from 780 +/- 21 to 1144 +/- 39 mg in five days. Similarly, in rats with established compensatory renal hypertrophy, diabetes induced a very rapid growth of the remaining kidney (1226 +/- 46 mg after five days).
已将实验性糖尿病诱导后大鼠肾脏的生长情况与单侧肾切除术后的代偿性肾脏生长进行了比较。五天后，一组对照组大鼠的肾脏重量从650±15毫克增加到糖尿病大鼠的778±21毫克，单侧肾切除大鼠的肾脏重量增加到764±17毫克。两组中体重的增加都反映在DNA含量增加以及RNA/DNA和蛋白质/DNA比率增加上。在一组同时进行糖尿病诱导和肾切除的大鼠中，五天后肾脏重量增加到953±22毫克。当大鼠在未经治疗的糖尿病20天后进行单侧肾切除时，代偿性生长比非糖尿病大鼠更为明显，肾脏重量在五天内从780±21毫克增加到1144±39毫克。同样，在已建立代偿性肾肥大的大鼠中，糖尿病诱导剩余肾脏非常快速地生长（五天后为1226±46毫克）。
