Purohit S D, Johri S C, Gupta P R, Mehta Y R, Bhatnagar M
Hospital for Chest and Tuberculosis, SMS Medical College, Jaipur, Rajasthan.
J Assoc Physicians India. 1992 May;40(5):308-10.
Newly diagnosed patients of pulmonary tuberculosis (n = 112) were put on a rifampicin-containing drug regimen. Fifty six patients were also given a placebo tablet twice daily while the other fifty-six were given ranitidine 150 mg twice daily. Gastric pH, gastric emptying time, serum rifampicin levels, urinary total and unchanged rifampicin, serum bilirubin and ALT levels were measured serially. Clinical record of adverse symptoms was maintained. Ranitidine increased the basal as well as post-drug gastric pH without altering the gastric emptying time. Concomitant administration of ranitidine and rifampicin did not alter the absorption, metabolism or excretion of the latter but reduced the frequency of gastrointestinal symptoms.
新诊断的肺结核患者（n = 112）采用含利福平的药物治疗方案。56名患者还每日两次服用安慰剂片，而另外56名患者则每日两次服用150毫克雷尼替丁。连续测量胃pH值、胃排空时间、血清利福平水平、尿中总利福平和未变化的利福平、血清胆红素和谷丙转氨酶水平。记录不良反应症状的临床情况。雷尼替丁增加了基础胃pH值以及用药后的胃pH值，而未改变胃排空时间。雷尼替丁与利福平同时给药并未改变利福平的吸收、代谢或排泄，但减少了胃肠道症状的发生频率。
