Saccone G T, Liu Y F, Thune A, Harvey J R, Baker R A, Toouli J
Department of Surgery, Flinders Medical Centre, Bedford Park, South Australia.
Naunyn Schmiedebergs Arch Pharmacol. 1992 Dec;346(6):701-6. doi: 10.1007/BF00168745.
The actions of erythromycin lactobionate and porcine motilin on trans-sphincteric flow and simultaneous sphincter of Oddi motility were studied in 15 anaesthetized Australian Brush-tailed possums (Trichosurus vulpecula). Erythromycin (25-200 micrograms/kg) and motilin (25-200 ng/kg) were administered as graded doses by close intraarterial injection. Trans-sphincteric flow was measured as inflow and outflow. Both motilin and erythromycin decreased trans-sphincteric inflow (both P < 0.0001) and outflow (P < 0.0001 and P = 0.0017 respectively) in a dose-dependent manner. The highest dose of each agent abolished trans-sphincteric flow. These agents increased sphincter of Oddi phasic contraction frequency and basal pressure up to 2 and 3 fold respectively (P < 0.05). The amplitude of the sphincter of Oddi phasic contractions were not influenced in any consistent fashion by either agent. The durations of the responses (trans-sphincteric inflow) elicited by erythromycin and motilin were dose dependent (P = 0.0225 and P = 0.0001 respectively). The actions of erythromycin (200 micrograms/kg) or motilin (100 ng/kg) on trans-sphincteric flow and sphincter of Oddi motility were not influenced by neural blockade with tetrodotoxin. These findings support the hypothesis that erythromycin acts as a motilin agonist and both substances increase the resistance to flow through the sphincter of Oddi by raising the basal pressure and frequency of contractions.
在15只麻醉的澳大利亚帚尾袋貂（帚尾袋貂）中研究了乳糖酸红霉素和猪胃动素对跨括约肌流量以及同时存在的Oddi括约肌运动的作用。通过动脉内近距离注射以分级剂量给予红霉素（25 - 200微克/千克）和胃动素（25 - 200纳克/千克）。跨括约肌流量通过流入量和流出量来测量。胃动素和红霉素均以剂量依赖性方式降低跨括约肌流入量（均P < 0.0001）和流出量（分别为P < 0.0001和P = 0.0017）。每种药物的最高剂量消除了跨括约肌流量。这些药物分别使Oddi括约肌的相性收缩频率和基础压力增加高达2倍和3倍（P < 0.05）。两种药物均未以任何一致的方式影响Oddi括约肌相性收缩的幅度。红霉素和胃动素引起的反应持续时间（跨括约肌流入量）呈剂量依赖性（分别为P = 0.0225和P = 0.0001）。红霉素（200微克/千克）或胃动素（100纳克/千克）对跨括约肌流量和Oddi括约肌运动的作用不受河豚毒素神经阻滞的影响。这些发现支持了以下假设，即红霉素作为胃动素激动剂起作用，并且两种物质通过提高基础压力和收缩频率来增加通过Oddi括约肌的流动阻力。
