13位亮氨酸胃动素对兔奥迪括约肌电活动的体内效应。

In vivo effect of 13 Leu motilin on the electric activity of the rabbit sphincter of Oddi.

作者信息

Sarles J C, Delecourt P, Devaux M A, Amoros J P, Guicheney J C, Wünsch E

出版信息

Horm Metab Res. 1981 Jun;13(6):340-2. doi: 10.1055/s-2007-1019261.

DOI:10.1055/s-2007-1019261

Abstract

Myoelectrical activity of the sphincter of Oddi was studied in 15 anaesthetized and laparotomized male rabbits, before and after injection of various doses of 13 Leucine Motilin (13 L Motilin), a biological and structural analogue of natural motilin. It can be concluded that 13 L Motilin provoked an increase of the sphincter of Oddi spike activity with doses ranging from 0.1 to 1.6 x 10(-6) g/kg. This effect had begun one minute after the injection, reached its maximum at the second minute and lasted for fifteen minutes. The action of 13 L Motilin is dose-related between 0.2 and 0.6 x 10(-6).

摘要

在15只麻醉并开腹的雄性兔子身上，研究了注射不同剂量的13-亮氨酸胃动素（13-L-胃动素）（一种天然胃动素的生物学和结构类似物）前后奥迪括约肌的肌电活动。可以得出结论，13-L-胃动素在剂量为0.1至1.6×10⁻⁶克/千克范围内可引起奥迪括约肌峰活动增加。这种作用在注射后1分钟开始，在第2分钟达到最大值，并持续15分钟。在0.2至0.6×10⁻⁶之间，13-L-胃动素的作用与剂量相关。