趋化因子对兔多形核白细胞膜“钠钾” -ATP酶的激活作用
Activation of the rabbit polymorphonuclear leukocyte membrane "Na+, K+"-ATPase by chemotactic factor.
作者信息
Becker E L, Talley V, Showell H J, Naccache P H, Sha'afi R I
出版信息
J Cell Biol. 1978 May;77(2):329-33. doi: 10.1083/jcb.77.2.329.
Abstract
Addition of the synthetic chemotactic factor, formyl-methionyl-leucyl-phenylala-nine (F-Met-Leu-Phe) to medium containing magnesium, sodium, and potassium results in a doubling of the "Na+, K+"-ATPase activity of the plasma membrane fraction from polymophonuclear leukocytes (PMN). This activation is sensitive to ouabain inhibition and is dose dependent, maximal activity occuring at 10(-9)MF-Met-Leu-Phe. Equivalent activation was observed with the nonformylated derivative Met-Leu-Phe at 10(-9)M. The dipeptide, carbobenzoxy-methionylphenylalanine, which acts as an antagonist for F-Met-Leu-Phe, prevents the stimulation of the "Na+, K+"-ATPase by F-Met-Leu-Phe.
摘要
在含有镁、钠和钾的培养基中添加合成趋化因子甲酰甲硫氨酰亮氨酰苯丙氨酸（F-Met-Leu-Phe），会使多形核白细胞（PMN）质膜部分的“Na +，K +”-ATP酶活性加倍。这种激活对哇巴因抑制敏感且呈剂量依赖性，最大活性出现在10（-9）M F-Met-Leu-Phe时。在10（-9）M时，未甲酰化的衍生物Met-Leu-Phe也观察到了同等程度的激活。作为F-Met-Leu-Phe拮抗剂的二肽苄氧羰基甲硫氨酰苯丙氨酸可阻止F-Met-Leu-Phe对“Na +，K +”-ATP酶的刺激。
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