Ploeger G E, Spruijt B M, Cools A R
Institute of Molecular Biology, and Medical Biotechnology, University of Utrecht, The Netherlands.
Physiol Behav. 1992 Nov;52(5):979-83. doi: 10.1016/0031-9384(92)90380-k.
The effects of systemic injections of the dopaminergic antagonist haloperidol on the acquisition of the Morris water maze with either a visible or an invisible platform (nonspatial vs. spatial learning) were investigated. An open field test was used for selecting a dosage (< or = 0.1 mg/kg), that (hardly) affected locomotor behaviour. Differential effects were found. At 0.1 mg/kg, haloperidol reduced locomotion in the open field, impaired acquisition in the Morris maze with a visible platform, and blocked escape onto an invisible one. Even though 0.07 mg/kg haloperidol reduced locomotion, both 0.04 and 0.07 mg/kg only impaired Morris maze performance in the spatial version. A large effect was found in the first trial of every day's training block. These results indicate that haloperidol at low doses can lead to a moderate but significant impairment of spatial learning. It is suggested that the effects found are related to the function of the striatal areas in cue- and noncue-directed behaviour.
研究了系统性注射多巴胺能拮抗剂氟哌啶醇对可见或不可见平台的莫里斯水迷宫学习（非空间学习与空间学习）的影响。采用旷场试验来选择一个（几乎）不影响运动行为的剂量（≤0.1mg/kg）。发现了不同的影响。0.1mg/kg时，氟哌啶醇减少了旷场中的运动，损害了可见平台莫里斯迷宫的学习，并阻碍了逃向不可见平台。尽管0.07mg/kg氟哌啶醇减少了运动，但0.04mg/kg和0.07mg/kg仅损害了空间版莫里斯迷宫的表现。在每天训练组的第一次试验中发现了很大的影响。这些结果表明，低剂量氟哌啶醇可导致空间学习中度但显著受损。有人认为，所发现的影响与纹状体区域在提示和非提示导向行为中的功能有关。
