Schrott L M, Denenberg V H, Sherman G F, Rosen G D, Galaburda A M
Biobehavioral Science Graduate Degree Program, University of Connecticut, Storrs 06269-4154.
Physiol Behav. 1992 Dec;52(6):1085-9. doi: 10.1016/0031-9384(92)90463-c.
In a prior study we found excellent Lashley III maze learning in BXSB mice and poor learning in NZB mice, despite the fact that both strains are autoimmune and develop cortical ectopias. This prompted us to examine NZB Lashley maze performance in detail, including comparisons to other strains and attempts to improve performance by giving additional trials with or without additional intramaze visual cues. In conventional Lashley testing (10 trials), RF mice (non-autoimmune and nonectopic) and BXSBs performed well in the Lashley maze. They had high learning indices and few errors. NZB mice performed poorly, with low learning indices and many errors. Even with additional trials or additional trials plus intramaze cues, NZB performance remained poor. The number of backward and forward errors stayed high; learning indices were low. Since both BXSB and NZB mice develop autoimmune disorders and cortical ectopias, it is unlikely that differential Lashley performance is the result of the presence of these phenomena. NZB mice are known to have alterations in their hippocampal morphology, and this is a possible mediator of the Lashley deficit.
在之前的一项研究中，我们发现BXSB小鼠在拉什利三世迷宫学习中表现出色，而NZB小鼠学习能力较差，尽管这两种品系都有自身免疫性且会出现皮质异位。这促使我们详细研究NZB小鼠在拉什利迷宫中的表现，包括与其他品系进行比较，以及尝试通过增加试验次数（有无额外的迷宫视觉线索）来提高其表现。在传统的拉什利测试（10次试验）中，RF小鼠（非自身免疫且无皮质异位）和BXSB小鼠在拉什利迷宫中表现良好。它们的学习指数高且错误少。NZB小鼠表现不佳，学习指数低且错误多。即使增加试验次数或增加试验次数并加上迷宫线索，NZB小鼠的表现仍然很差。前后向错误的数量仍然很高；学习指数很低。由于BXSB和NZB小鼠都会出现自身免疫性疾病和皮质异位，拉什利表现的差异不太可能是这些现象存在的结果。已知NZB小鼠的海马形态有改变，这可能是拉什利缺陷的一个介导因素。
