Leung L S, Boon K A, Kaibara T, Innis N K
Department of Clinical Neurological Sciences, Physiology, University of Western Ontario, London, Canada.
Behav Brain Res. 1990 Nov 15;40(2):119-29. doi: 10.1016/0166-4328(90)90004-x.
The relation between hippocampal epileptiform activity and 8-arm radial maze performance was assessed following repetitive afterdischarges (ADs) evoked by stimulation of the hippocampal CA1 region (kindling). Hippocampal kindling, whether to stage V (generalized) convulsions or to a preconvulsive stage, induced deficits in radial maze performance, evaluated by correct arm entries in 8 choices or total maze run (trial) time. The deficits persisted at least until 21 days after the last AD. Hippocampal interictal spikes (ISs) were induced by kindling, but the rate of ISs declined to near zero in a few days. The rate or presence of ISs was not related to maze performance.
通过刺激海马CA1区诱发重复性后放电（ADs）（点燃）后，评估海马癫痫样活动与八臂放射状迷宫行为表现之间的关系。海马点燃，无论是达到V期（全身性）惊厥还是处于惊厥前期，都会导致放射状迷宫行为表现出现缺陷，通过八次选择中的正确臂进入次数或总迷宫运行（试验）时间来评估。这些缺陷至少持续到最后一次AD后21天。海马发作间期棘波（ISs）由点燃诱发，但ISs的发生率在几天内降至接近零。ISs的发生率或存在与否与迷宫行为表现无关。
