Nakamura K, Tsuchiya S, Sugimoto Y, Sugimura Y, Yamada Y
Tochigi Research Laboratories, Kao Corporation, Tochigi, Japan.
Planta Med. 1992 Dec;58(6):505-8. doi: 10.1055/s-2006-961536.
Eleven examples of bisbenzylisoquinoline alkaloids (head-to-head; 10, head-to-tail; 1) and one half molecule type (N-methylcoclaurine), were tested by in vitro histamine release inhibition assay. The order of the potency of the inhibitory effect was ranked thus: homoaromoline, aromoline, isotetrandrine, cepharanthine, fangchinoline, obaberine, and tetrandrine. The following substances, cepharanoline, berbamine, oxyacanthine, and cycleanine (head-to-tail structure) had no inhibitory effect. N-Methylcoclaurine showed an inhibitory effect comparable to that of fangchinoline.
通过体外组胺释放抑制试验对11个双苄基异喹啉生物碱实例（头对头；10个，头尾相连；1个）和1个半分子类型（N-甲基荷包牡丹碱）进行了测试。抑制作用的效力顺序如下：高阿罗莫林、阿罗莫林、异粉防己碱、汉防己甲素、粉防己碱、去甲小檗碱和粉防己碱。以下物质，头孢罗啉、小檗胺、刺芒柄花素和环宁（头尾结构）没有抑制作用。N-甲基荷包牡丹碱显示出与粉防己碱相当的抑制作用。
