Hoffmann-Bohm K, Lotter H, Seligmann O, Wagner H
Institut of Pharmaceutical Biology, Ludwig-Maximilians-University of Munich, Federal Republic of Germany.
Planta Med. 1992 Dec;58(6):544-8. doi: 10.1055/s-2006-961546.
From the leaves of Allophyllus edulis var. edulis and Allophyllus edulis var. gracilis nine C-glycosylflavones have been isolated and identified as schaftoside (8), vicenin-2 (9), lucenin-2 (10), isovitexin 2"-O-rhamnoside (11), cerarvensin 2"-O-rhamnoside (12), vitexin 2"-O-rhamnoside (13), isoorientin 2"-O-rhamnoside (15), orientin 2"-O-rhamnoside (16) and saponarin (17). In addition, gallic acid (2), the phenol C-glycosides bergenin (3) and 11-O-galloylbergenin (4), three flavonol 3-O-rhamnosides and a new C-glycosylflavone identified as mollupentin 2"-O-rhamnoside (14) were obtained from the leaves of Allophyllus edulis var. edulis. Their structures were elucidated on the basis of chemical and spectral data. For the first time the C-glycosylflavones were found to have remarkable anti-hepatotoxic activities against CCl4 and galactosamine cytotoxicity in primary cultured rat hepatocytes. Structure-activity relationships are discussed.
从食用异木患（Allophyllus edulis var. edulis）和细叶异木患（Allophyllus edulis var. gracilis）的叶子中分离并鉴定出了9种C-糖基黄酮，分别为schaftoside（8）、异荭草苷（9）、异槲皮苷（10）、异牡荆素2″-O-鼠李糖苷（11）、cerarvensin 2″-O-鼠李糖苷（12）、牡荆素2″-O-鼠李糖苷（13）、异荭草素2″-O-鼠李糖苷（15）、荭草素2″-O-鼠李糖苷（16）和肥皂草苷（17）。此外，从食用异木患的叶子中还获得了没食子酸（2）、酚C-糖苷岩白菜素（3）和11-O-没食子酰岩白菜素（4）、三种黄酮醇3-O-鼠李糖苷以及一种新的C-糖基黄酮，鉴定为软木草苷2″-O-鼠李糖苷（14）。它们的结构通过化学和光谱数据得以阐明。首次发现这些C-糖基黄酮对原代培养大鼠肝细胞中的CCl4和半乳糖胺细胞毒性具有显著的抗肝毒性活性。并对构效关系进行了讨论。
