Ezura M, Kagawa S
Department of Neurosurgery, Shirakawa Kosei Hospital, Japan.
Surg Neurol. 1992 Nov;38(5):353-8. doi: 10.1016/0090-3019(92)90021-e.
Intraarterial administration of urokinase using Tracker microcatheter was performed in 11 patients with acute cerebral infarction caused by embolic occlusion of the internal carotid or the middle cerebral artery. Recanalization was observed in seven cases (64%) following the fibrinolytic therapy, and the time until recanalization from the start of the treatment was on the average 2.8 hours. Recanalization was seen in five out of six cases that received superselective infusion of urokinase, while it was seen in two out of five cases that received selective infusion. This study suggests that superselective infusion of urokinase is an excellent therapeutic method for embolic occlusion of the cerebral artery.
使用Tracker微导管对11例因颈内动脉或大脑中动脉栓塞性闭塞导致急性脑梗死的患者进行动脉内尿激酶给药。溶栓治疗后，7例（64%）出现再通，从治疗开始到再通的平均时间为2.8小时。接受尿激酶超选择性输注的6例患者中有5例出现再通，而接受选择性输注的5例患者中有2例出现再通。本研究表明，尿激酶超选择性输注是治疗脑动脉栓塞性闭塞的一种优秀治疗方法。
