Kennedy M J
Veterinary Pathology Branch, Alberta Department of Agriculture, Edmonton, Canada.
Vet Parasitol. 1992 Dec;45(1-2):127-31. doi: 10.1016/0304-4017(92)90034-7.
The anthelmintic efficacy of ivermectin (administered subcutaneously at 200 micrograms kg-1 body weight) was assessed for control of Thelazia skrjabini in experimentally infected calves. Twenty-four uninfected male Holstein calves, 1-2 weeks old, were artificially infected with Thelazia skrjabini by placing 15 third-stage larvae under the third eyelid of calves. The challenge larvae were recovered from naturally infected face flies, Musca autumnalis. The exposed calves were randomly assigned to either an ivermectin treatment group or a control group within pairs ranked by weight. Equal numbers of calves were housed in each of four indoor fly-free rooms. The calves were treated with ivermectin or saline 35 days post-infection, then slaughtered 14 days later to determine eyeworm numbers. All eyes and associated tissues (including the lacrimal glands and ducts) were removed and examined for total number, species and viability of eyeworms. Thelazia skrjabini was found in the control group of calves only. The efficacy of ivermectin against Thelazia skrjabini was thus shown to be 100%.
评估了伊维菌素（以200微克/千克体重皮下注射）对实验感染犊牛体内斯氏吸吮线虫的驱虫效果。24头1 - 2周龄未感染的雄性荷斯坦犊牛，通过在犊牛第三眼睑下放15条第三期幼虫人工感染斯氏吸吮线虫。攻击幼虫取自自然感染的秋家蝇。将暴露的犊牛按体重配对后随机分为伊维菌素治疗组或对照组。四个无蝇室内房间中每个房间饲养数量相等的犊牛。感染后35天，给犊牛注射伊维菌素或生理盐水，14天后宰杀以确定眼虫数量。摘除所有眼睛及相关组织（包括泪腺和泪管），检查眼虫的总数、种类和活力。仅在犊牛对照组中发现了斯氏吸吮线虫。因此，伊维菌素对斯氏吸吮线虫的驱虫效果显示为100%。
