Kennedy M J, Holste J E, Jacobsen J A
Alberta Agriculture, Animal Health Laboratories Branch, Edmonton, Canada.
Vet Parasitol. 1994 Nov;55(3):263-6. doi: 10.1016/0304-4017(93)00644-E.
Sixteen crossbred beef cattle, 6-8 months of age, were used to determine the efficacy of ivermectin in a pour-on formulation against natural infections of Thelazia spp. Cattle were weighed on Day 0, ranked in descending order by bodyweight and sequentially paired. Within each pair, one animal was randomly assigned to an untreated control group, while the other animal was treated with a pour-on formulation of ivermectin applied topically at 1.0 ml per 10 kg bodyweight to achieve a dosage of 500 mg ivermectin kg-1 body weight. On Day 14 all animals in both treatment groups were slaughtered. The eyes and surrounding tissues were removed and examined for eyeworms. A total of 86 adult worms (74 Thelazia skrjabini and 12 Thelazia gulosa) were recovered from the untreated control animals. T. skrjabini was found in seven, and T. gulosa in three, of the eight untreated control animals. Two T. skrjabini, one from each of two animals, were found on the surface of the eyes of cattle that had received ivermectin treatment. The reduction in the geometric mean number for T. gulosa collected from treated animals was 100% (P > 0.1) relative to controls, and 97.02% (P = 0.0025) for T. skrjabini relative to controls.
选用16头6 - 8月龄的杂交肉牛，以确定浇泼剂伊维菌素对吸吮线虫属自然感染的疗效。在第0天对牛进行称重，按体重从大到小排序并依次配对。在每一对中，一只动物被随机分配到未处理的对照组，而另一只动物则用伊维菌素浇泼剂进行处理，按每10千克体重1.0毫升的剂量局部给药，以达到500毫克伊维菌素/千克体重的剂量。在第14天，对两个治疗组的所有动物进行屠宰。取出眼睛及周围组织检查是否有眼虫。从未处理的对照动物中总共回收了86条成虫（74条斯氏吸吮线虫和12条大口吸吮线虫）。在8只未处理的对照动物中，7只发现了斯氏吸吮线虫，3只发现了大口吸吮线虫。在接受伊维菌素治疗的牛的眼睛表面发现了2条斯氏吸吮线虫，分别来自两只动物。相对于对照组，从治疗动物中收集到的大口吸吮线虫的几何平均数减少了100%（P>0.1），斯氏吸吮线虫减少了97.02%（P = 0.0025）。
